The role of 2,3-DPG in the intraerythrocytic adaptation to various types of hypoxaemia is described. The increased oxygen affinity of blood stored in acid-citrate-dextrose ACD solution has been shown to be due to the decrease in the concentration of 2,3-DPG which occurs during storage.
Methods of maintaining the concentration of 2,3-DPG in stored blood are described. The clinical implication of transfusion of elderly people, anaemic or pregnant patients with ACD stored blood to anaesthetically and surgically acceptable haemoglobin concentrations are discussed. Hypophosphataemia in association with parenteral feeding reduces 2,3-DPG concentration and so increases oxygen affinity. Skip to main content. Pathway Medicine.
Search form Search. Book navigation Immunology. Cardiovascular Medicine. Renal Medicine. News trends on 2,3-Bisphosphoglycerate. Blogs on 2,3-Bisphosphoglycerate. Definitions of 2,3-Bisphosphoglycerate. Patient resources on 2,3-Bisphosphoglycerate. Discussion groups on 2,3-Bisphosphoglycerate. Patient Handouts on 2,3-Bisphosphoglycerate. Directions to Hospitals Treating 2,3-Bisphosphoglycerate. Risk calculators and risk factors for 2,3-Bisphosphoglycerate.
Symptoms of 2,3-Bisphosphoglycerate. Diagnostic studies for 2,3-Bisphosphoglycerate. Treatment of 2,3-Bisphosphoglycerate. CME Programs on 2,3-Bisphosphoglycerate. Patents on 2,3-Bisphosphoglycerate. List of terms related to 2,3-Bisphosphoglycerate. Editor-In-Chief: C. Michael Gibson, M. It binds with greater affinity to deoxygenated hemoglobin e.
In bonding to partially deoxygenated hemoglobin it allosterically upregulates the release of the remaining oxygen molecules bound to the hemoglobin, thus enhancing the ability of RBCs to release oxygen near tissues that need it most.
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